Introducing: The 3 Ps In 90 Days
Introducing: The 3 Ps In 90 Days
Mastering the 3 Ps in just 90 days...
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Good morning, friends and colleagues!
Today’s an EXCITING day for us here at The USMLE Guys…
We’ve gathered the data and asked our students what they want the most help with…
The results?
A better way to learn the 3 Ps (Pharm, Path, & Physio).
Surprisingly, no course or product out there focuses exclusively on the 3 Ps—odd, right?
So we’re bringing it to you! Right here on Substack.
Here’s how it works…
We’ve put together ninety (90) cases…
Over the ninety cases, the most important, high-yield, highly-tested 3 Ps concepts will be tested.
Each case contains the following:
1) A case scenario (everything begins with a scenario)
2) Three questions: 1 physiology, 1 pharmacology, and 1 pathology
3) Key Points: The concepts you need to learn for each of the three questions
4) Flashcard questions: Twenty one-liners to help you review the information
Your job is to go through each case and answer the questions.
You’ll then get a detailed breakdown of each question and how the “key points” are integral to your mastery of the topic being covered. This includes everything, from top to bottom, that you’ll need to walk away from each day’s case with complete mastery of the important pharmacology, physiology, and pathology concepts being tested and taught.
Each day, you will focus on one (1) concept for each of the 3 Ps… Thus, you will master one concept from pharm, one from physio, and one from path.
We’ll be dropping a new case every day at 7am Eastern time. You’ll get an email when it’s live if you’re a subscriber. If you’re not yet subscribed to our Substack account, you’ll see an email prompt box below:
The first five days are available to all subscribers!
*THIS COURSE GOES LIVE IF/WHEN THIS POST GETS 500 LIKES*
Here’s the full list of our anticipated daily topics from day 1-90:
Day 1. Acute Myocardial Infarction (AMI)
Physiology: Coronary blood flow and myocardial oxygen demand.
Pathology: Histopathological changes in myocardial tissue post-ischemia.
Pharmacology: Initial and long-term pharmacological management.
Day 2. Acute Respiratory Distress Syndrome (ARDS)
Physiology: Gas exchange and ventilation-perfusion mismatch.
Pathology: Diffuse alveolar damage and neutrophilic alveolitis.
Pharmacology: Use of corticosteroids and mechanical ventilation strategies.
Day 3. Parkinson's Disease
Physiology: Role of dopamine in motor control.
Pathology: Loss of dopaminergic neurons and Lewy bodies.
Pharmacology: Levodopa and other dopaminergic treatments.
Day 4. Cirrhosis and Cardiovascular Changes
Physiology: Hyperdynamic circulation and portal hypertension.
Pathology: Cirrhotic cardiomyopathy and vascular abnormalities.
Pharmacology: Management of complications like ascites and varices.
Day 5. Acute Pyelonephritis
Physiology: Renal blood flow and filtration.
Pathology: Inflammatory changes in the renal pelvis and parenchyma.
Pharmacology: Antibiotic treatment and pain management.
Day 6. Glomerulonephritis
Physiology: Glomerular filtration and renal function.
Pathology: Immune-mediated damage to glomeruli.
Pharmacology: Immunosuppressive therapy.
Day 7. Rheumatoid Arthritis
Physiology: Joint function and immune response.
Pathology: Synovial inflammation and joint destruction.
Pharmacology: DMARDs and biologics.
Day 8. Type 2 Diabetes Mellitus
Physiology: Insulin secretion and glucose metabolism.
Pathology: Beta-cell dysfunction and insulin resistance.
Pharmacology: Oral hypoglycemics and insulin therapy.
Day 9. Lung Cancer
Physiology: Respiratory mechanics and gas exchange.
Pathology: Genetic mutations and tumor progression.
Pharmacology: Chemotherapy and targeted therapies.
Day 10. Acute Myeloid Leukemia (AML)
Physiology: Hematopoiesis and bone marrow function.
Pathology: Clonal expansion of myeloid blasts.
Pharmacology: Chemotherapy regimens and stem cell transplantation.
Day 11. Hypertension
Physiology: Blood pressure regulation and vascular resistance.
Pathology: Hypertensive vascular damage.
Pharmacology: Antihypertensive medications.
Day 12. Chronic Obstructive Pulmonary Disease (COPD)
Physiology: Airflow limitation and gas exchange.
Pathology: Emphysema and chronic bronchitis.
Pharmacology: Bronchodilators and corticosteroids.
Day 13. Heart Failure
Physiology: Cardiac output and preload/afterload.
Pathology: Myocardial remodeling and ventricular dysfunction.
Pharmacology: ACE inhibitors, beta-blockers, and diuretics.
Day 14. Asthma
Physiology: Airway reactivity and bronchoconstriction.
Pathology: Inflammatory changes in the airways.
Pharmacology: Inhaled corticosteroids and bronchodilators.
Day 15. Peptic Ulcer Disease
Physiology: Gastric acid secretion and mucosal protection.
Pathology: Ulcer formation and Helicobacter pylori infection.
Pharmacology: Proton pump inhibitors and antibiotics.
Day 16. Hyperthyroidism
Physiology: Thyroid hormone production and metabolism.
Pathology: Graves' disease and thyroid nodules.
Pharmacology: Antithyroid medications and beta-blockers.
Day 17. Hypothyroidism
Physiology: Thyroid hormone regulation.
Pathology: Hashimoto's thyroiditis and thyroid atrophy.
Pharmacology: Levothyroxine replacement therapy.
Day 18. Acute Kidney Injury (AKI)
Physiology: Renal perfusion and filtration.
Pathology: Ischemic and nephrotoxic injury.
Pharmacology: Supportive care and dialysis.
Day 19. Hepatitis
Physiology: Liver function and bile production.
Pathology: Viral hepatitis and liver inflammation.
Pharmacology: Antiviral medications and immunomodulators.
Day 20. Multiple Sclerosis
Physiology: Nerve conduction and myelination.
Pathology: Demyelination and neuroinflammation.
Pharmacology: Immunomodulatory therapy.
Day 21. Alzheimer's Disease
Physiology: Cognitive function and neurotransmitter activity.
Pathology: Amyloid plaques and neurofibrillary tangles.
Pharmacology: Cholinesterase inhibitors and NMDA receptor antagonists.
Day 22. Osteoarthritis
Physiology: Joint mechanics and cartilage function.
Pathology: Degenerative changes in articular cartilage.
Pharmacology: NSAIDs and joint injections.
Day 23. Systemic Lupus Erythematosus (SLE)
Physiology: Immune regulation and autoimmunity.
Pathology: Multisystem inflammatory damage.
Pharmacology: Corticosteroids and immunosuppressants.
Day 24. Acute Pancreatitis
Physiology: Pancreatic enzyme secretion.
Pathology: Inflammation and autodigestion of the pancreas.
Pharmacology: Pain management and enzyme replacement.
Day 25. Chronic Kidney Disease (CKD)
Physiology: Renal function and electrolyte balance.
Pathology: Progressive nephron loss and fibrosis.
Pharmacology: ACE inhibitors and phosphate binders.
Day 26. Anemia
Physiology: Erythropoiesis and oxygen transport.
Pathology: Iron deficiency and hemolysis.
Pharmacology: Iron supplements and erythropoiesis-stimulating agents.
Day 27. Cystic Fibrosis
Physiology: Chloride transport and mucus production.
Pathology: Genetic mutations and respiratory complications.
Pharmacology: CFTR modulators and mucolytics.
Day 28. Hyperlipidemia
Physiology: Lipid metabolism and transport.
Pathology: Atherosclerosis and cardiovascular risk.
Pharmacology: Statins and fibrates.
Day 29. Gout
Physiology: Uric acid metabolism.
Pathology: Crystal deposition and joint inflammation.
Pharmacology: NSAIDs and urate-lowering therapy.
Day 30. Inflammatory Bowel Disease (IBD)
Physiology: Gut immunity and barrier function.
Pathology: Crohn's disease and ulcerative colitis.
Pharmacology: Aminosalicylates and biologics.
Day 31. Stroke
Physiology: Cerebral blood flow and neuronal function.
Pathology: Ischemic and hemorrhagic stroke.
Pharmacology: Thrombolytics and antiplatelet agents.
Day 32. Sepsis
Physiology: Immune response and systemic inflammation.
Pathology: Multiorgan dysfunction and septic shock.
Pharmacology: Antibiotics and vasopressors.
Day 33. Pulmonary Embolism
Physiology: Pulmonary circulation and gas exchange.
Pathology: Thromboembolism and vascular occlusion.
Pharmacology: Anticoagulants and thrombolytics.
Day 34. Deep Vein Thrombosis (DVT)
Physiology: Coagulation cascade and blood flow.
Pathology: Venous thrombosis and inflammation.
Pharmacology: Anticoagulants and compression therapy.
Day 35. Pneumonia
Physiology: Respiratory defense mechanisms.
Pathology: Infectious inflammation of the lungs.
Pharmacology: Antibiotics and supportive care.
Day 36. Tuberculosis
Physiology: Immune response to Mycobacterium tuberculosis.
Pathology: Granuloma formation and lung damage.
Pharmacology: Antitubercular drugs.
Day 37. Hyperparathyroidism
Physiology: Calcium homeostasis and parathyroid hormone function.
Pathology: Parathyroid adenoma and hypercalcemia.
Pharmacology: Calcimimetics and bisphosphonates.
Day 38. Hypoparathyroidism
Physiology: Calcium and phosphate regulation.
Pathology: Parathyroid gland dysfunction.
Pharmacology: Calcium supplements and vitamin D analogs.
Day 39. Addison's Disease
Physiology: Adrenal hormone production.
Pathology: Adrenal insufficiency and autoimmune destruction.
Pharmacology: Corticosteroid replacement therapy.
Day 40. Cushing's Syndrome
Physiology: Cortisol regulation and stress response.
Pathology: Hypercortisolism and adrenal tumors.
Pharmacology: Ketoconazole and surgical intervention.
Day 41. Polycystic Ovary Syndrome (PCOS)
Physiology: Ovarian function and hormone regulation.
Pathology: Hyperandrogenism and insulin resistance.
Pharmacology: Metformin and oral contraceptives.
Day 42. Endometriosis
Physiology: Menstrual cycle and endometrial tissue growth.
Pathology: Ectopic endometrial implants and inflammation.
Pharmacology: Hormonal therapy and pain management.
Day 43. Benign Prostatic Hyperplasia (BPH)
Physiology: Prostate gland function and urinary flow.
Pathology: Prostatic enlargement and bladder outlet obstruction.
Pharmacology: Alpha-blockers and 5-alpha reductase inhibitors.
Day 44. Prostate Cancer
Physiology: Androgen regulation and prostate function.
Pathology: Malignant transformation of prostatic cells.
Pharmacology: Androgen deprivation therapy and chemotherapy.
Day 45. Breast Cancer
Physiology: Hormonal regulation of breast tissue.
Pathology: Genetic mutations and tumor progression.
Pharmacology: Hormonal therapy and targeted treatments.
Day 46. Colorectal Cancer
Physiology: Gastrointestinal function and nutrient absorption.
Pathology: Adenomatous polyps and malignant transformation.
Pharmacology: Chemotherapy and monoclonal antibodies.
Day 47. Hepatocellular Carcinoma
Physiology: Liver function and metabolism.
Pathology: Cirrhosis and malignant transformation.
Pharmacology: Sorafenib and locoregional therapies.
Day 48. Pancreatic Cancer
Physiology: Exocrine and endocrine functions of the pancreas.
Pathology: Genetic mutations and tumor progression.
Pharmacology: Chemotherapy and targeted treatments.
Day 49. Osteoporosis
Physiology: Bone remodeling and calcium metabolism.
Pathology: Decreased bone density and fragility fractures.
Pharmacology: Bisphosphonates and calcium/vitamin D supplements.
Day 50. Hypercalcemia
Physiology: Calcium homeostasis and hormonal regulation.
Pathology: Malignancy and hyperparathyroidism.
Pharmacology: Bisphosphonates and calcitonin.
Day 51. Hypocalcemia
Physiology: Calcium and phosphate balance.
Pathology: Hypoparathyroidism and vitamin D deficiency.
Pharmacology: Calcium supplements and vitamin D analogs.
Day 52. Hyperkalemia
Physiology: Potassium homeostasis and renal function.
Pathology: Renal failure and acidosis.
Pharmacology: Potassium binders and diuretics.
Day 53. Hypokalemia
Physiology: Potassium regulation and cellular function.
Pathology: Diuretic use and gastrointestinal losses.
Pharmacology: Potassium supplements and dietary modifications.
Day 54. Hyponatremia
Physiology: Sodium and water balance.
Pathology: SIADH and heart failure.
Pharmacology: Fluid restriction and hypertonic saline.
Day 55. Hypernatremia
Physiology: Sodium regulation and osmoregulation.
Pathology: Dehydration and diabetes insipidus.
Pharmacology: Fluid replacement and desmopressin.
Day 56. Hypomagnesemia
Physiology: Magnesium homeostasis and cellular function.
Pathology: Malnutrition and chronic alcoholism.
Pharmacology: Magnesium supplements.
Day 57. Hypermagnesemia
Physiology: Magnesium regulation and renal function.
Pathology: Renal failure and excessive supplementation.
Pharmacology: Calcium gluconate and dialysis.
Day 58. Hypophosphatemia
Physiology: Phosphate metabolism and cellular energy.
Pathology: Refeeding syndrome and hyperparathyroidism.
Pharmacology: Phosphate supplements.
Day 59. Hyperphosphatemia
Physiology: Phosphate balance and renal excretion.
Pathology: Chronic kidney disease and tumor lysis syndrome.
Pharmacology: Phosphate binders.
Day 60. Sickle Cell Disease
Physiology: Hemoglobin function and oxygen transport.
Pathology: Vaso-occlusive crises and hemolysis.
Pharmacology: Hydroxyurea and pain management.
Day 61. Hemophilia
Physiology: Coagulation cascade and clot formation.
Pathology: Factor VIII or IX deficiency.
Pharmacology: Factor replacement therapy.
Day 62. Von Willebrand Disease
Physiology: Platelet adhesion and coagulation.
Pathology: Von Willebrand factor deficiency.
Pharmacology: Desmopressin and factor replacement.
Day 63. Thalassemia
Physiology: Hemoglobin synthesis and oxygen transport.
Pathology: Genetic mutations and ineffective erythropoiesis.
Pharmacology: Blood transfusions and iron chelation.
Day 64. Aplastic Anemia
Physiology: Bone marrow function and hematopoiesis.
Pathology: Bone marrow failure and pancytopenia.
Pharmacology: Immunosuppressive therapy and bone marrow transplantation.
Day 65. Myelodysplastic Syndromes
Physiology: Hematopoiesis and cellular differentiation.
Pathology: Clonal hematopoiesis and ineffective erythropoiesis.
Pharmacology: Hypomethylating agents and supportive care.
Day 66. Chronic Myeloid Leukemia (CML)
Physiology: Hematopoiesis and leukocyte function.
Pathology: BCR-ABL fusion gene and clonal expansion.
Pharmacology: Tyrosine kinase inhibitors.
Day 67. Hodgkin's Lymphoma
Physiology: Immune function and lymphocyte regulation.
Pathology: Reed-Sternberg cells and lymph node involvement.
Pharmacology: Chemotherapy and radiation therapy.
Day 68. Non-Hodgkin's Lymphoma
Physiology: Lymphocyte function and immune response.
Pathology: Clonal expansion of B or T lymphocytes.
Pharmacology: Chemotherapy and monoclonal antibodies.
Day 69. Multiple Myeloma
Physiology: Plasma cell function and immunoglobulin production.
Pathology: Clonal proliferation of plasma cells.
Pharmacology: Proteasome inhibitors and immunomodulatory drugs.
Day 70. Acute Lymphoblastic Leukemia (ALL)
Physiology: Lymphoid progenitor cell function.
Pathology: Clonal expansion of lymphoblasts.
Pharmacology: Chemotherapy and targeted therapy.
Day 71. Chronic Lymphocytic Leukemia (CLL)
Physiology: Lymphocyte function and immune regulation.
Pathology: Clonal expansion of mature B lymphocytes.
Pharmacology: Chemotherapy and monoclonal antibodies.
Day 72. Hemochromatosis
Physiology: Iron metabolism and storage.
Pathology: Genetic mutations and iron overload.
Pharmacology: Phlebotomy and iron chelation.
Day 73. Wilson's Disease
Physiology: Copper metabolism and excretion.
Pathology: Genetic mutations and copper accumulation.
Pharmacology: Chelation therapy and zinc supplementation.
Day 74. Phenylketonuria (PKU)
Physiology: Amino acid metabolism.
Pathology: Phenylalanine hydroxylase deficiency.
Pharmacology: Dietary management and enzyme replacement.
Day 75. Cystinuria
Physiology: Amino acid transport and renal function.
Pathology: Genetic mutations and cystine stone formation.
Pharmacology: High fluid intake and alkalinizing agents.
Day 76. Hyperuricemia and Gout
Physiology: Uric acid metabolism.
Pathology: Crystal deposition and join destruction.
Pharmacology: Uric acid pharmacology.
Day 77. Acute Lymphoblastic Leukemia (ALL)
Physiology: Lymphoid progenitor cell function.
Pathology: Clonal expansion of lymphoblasts.
Pharmacology: Chemotherapy and targeted therapy.
Day 78. Chronic Lymphocytic Leukemia (CLL)
Physiology: Lymphocyte function and immune regulation.
Pathology: Clonal expansion of mature B lymphocytes.
Pharmacology: Chemotherapy and monoclonal antibodies.
Day 79. Hemochromatosis
Physiology: Iron metabolism and storage.
Pathology: Genetic mutations and iron overload.
Pharmacology: Phlebotomy and iron chelation.
Day 80. Wilson's Disease
Physiology: Copper metabolism and excretion.
Pathology: Genetic mutations and copper accumulation.
Pharmacology: Chelation therapy and zinc supplementation.
Day 81. Phenylketonuria (PKU)
Physiology: Amino acid metabolism.
Pathology: Phenylalanine hydroxylase deficiency.
Pharmacology: Dietary management and enzyme replacement.
Day 82. Cystinuria
Physiology: Amino acid transport and renal function.
Pathology: Genetic mutations and cystine stone formation.
Pharmacology: High fluid intake and alkalinizing agents.
Day 83. Hyperuricemia and Gout
Physiology: Uric acid metabolism.
Pathology: Crystal deposition and joint inflammation.
Pharmacology: NSAIDs and urate-lowering therapy.
Day 84. Hyperaldosteronism (Conn's Syndrome)
Physiology: Aldosterone regulation and electrolyte balance.
Pathology: Adrenal adenoma and hyperplasia.
Pharmacology: Spironolactone and surgical intervention.
Day 85. Pheochromocytoma
Physiology: Catecholamine synthesis and release.
Pathology: Adrenal medulla tumor.
Pharmacology: Alpha-blockers and surgical resection.
Day 86. Acromegaly
Physiology: Growth hormone regulation.
Pathology: Pituitary adenoma and somatic overgrowth.
Pharmacology: Somatostatin analogs and surgical resection.
Day 87. Diabetes Insipidus
Physiology: ADH regulation and water balance.
Pathology: Central vs. nephrogenic diabetes insipidus.
Pharmacology: Desmopressin and thiazide diuretics.
Day 88. Syndrome of Inappropriate ADH Secretion (SIADH)
Physiology: ADH function and osmoregulation.
Pathology: Ectopic ADH production and hyponatremia.
Pharmacology: Fluid restriction and vasopressin antagonists.
Day 89. Hypopituitarism
Physiology: Pituitary hormone regulation.
Pathology: Pituitary adenoma and Sheehan's syndrome.
Pharmacology: Hormone replacement therapy.
Day 90. Hyperprolactinemia
Physiology: Prolactin regulation and reproductive function.
Pathology: Prolactinoma and hypothyroidism.
Pharmacology: Dopamine agonists and surgical resection.
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